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The function neutralizing anti-TrkA antibody MNAC13 reduces inflammatory and neuropathic pain

Nerve growth factor (NGF) is involved in pain transduction mechanisms and plays a key role in many persistent pain states, notably those associated with inflammation. On this basis, both the NGF ligand and its receptor TrkA (tyrosine kinase A) represent an eligible target for pain therapy. Although...

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Bibliografiske detaljer
Main Authors: Ugolini, Gabriele, Marinelli, Sara, Covaceuszach, Sonia, Cattaneo, Antonino, Pavone, Flaminia
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2007
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1815293/
https://ncbi.nlm.nih.gov/pubmed/17301229
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0611253104
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