Taking Pain Out of NGF: A “Painless” NGF Mutant, Linked to Hereditary Sensory Autonomic Neuropathy Type V, with Full Neurotrophic Activity

During adulthood, the neurotrophin Nerve Growth Factor (NGF) sensitizes nociceptors, thereby increasing the response to noxious stimuli. The relationship between NGF and pain is supported by genetic evidence: mutations in the NGF TrkA receptor in patients affected by an hereditary rare disease (Here...

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Detalhes bibliográficos
Main Authors: Capsoni, Simona, Covaceuszach, Sonia, Marinelli, Sara, Ceci, Marcello, Bernardo, Antonietta, Minghetti, Luisa, Ugolini, Gabriele, Pavone, Flaminia, Cattaneo, Antonino
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2011
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3046150/
https://ncbi.nlm.nih.gov/pubmed/21387003
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0017321
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