Intranasal “painless” Human Nerve Growth Factors Slows Amyloid Neurodegeneration and Prevents Memory Deficits in App X PS1 Mice

Nerve Growth Factor (NGF) is being considered as a therapeutic candidate for Alzheimer's disease (AD) treatment but the clinical application is hindered by its potent pro-nociceptive activity. Thus, to reduce systemic exposure that would induce pain, in recent clinical studies NGF was administe...

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Detalhes bibliográficos
Main Authors: Capsoni, Simona, Marinelli, Sara, Ceci, Marcello, Vignone, Domenico, Amato, Gianluca, Malerba, Francesca, Paoletti, Francesca, Meli, Giovanni, Viegi, Alessandro, Pavone, Flaminia, Cattaneo, Antonino
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3364340/
https://ncbi.nlm.nih.gov/pubmed/22666365
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0037555
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