Sterol regulation of human fatty acid synthase promoter I requires nuclear factor-Y- and Sp-1-binding sites

To understand cholesterol-mediated regulation of human fatty acid synthase promoter I, we tested various 5′-deletion constructs of promoter I-luciferase reporter gene constructs in HepG2 cells. The reporter gene constructs that contained only the Sp-1-binding site (nucleotides −82 to −74) and the tw...

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Dettagli Bibliografici

Pubblicato in:	Proc Natl Acad Sci U S A
Autori principali:	Xiong, Shunbin, Chirala, Subrahmanyam S., Wakil, Salih J.
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	National Academy of Sciences 2000
Soggetti:	Biological Sciences
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC18122/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10759542/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.040574197
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