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PTEN Induces Cell Cycle Arrest by Decreasing the Level and Nuclear Localization of Cyclin D1
PTEN is a tumor suppressor frequently inactivated in brain, prostate, and uterine cancers that acts as a phosphatase on phosphatidylinositol-3,4,5-trisphosphate, antagonizing the activity of the phosphatidylinositol 3′-OH kinase. PTEN manifests its tumor suppressor function in most tumor cells by in...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
American Society for Microbiology
2003
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC180959/ https://ncbi.nlm.nih.gov/pubmed/12917336 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.23.17.6139-6149.2003 |
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