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PTEN Induces Cell Cycle Arrest by Decreasing the Level and Nuclear Localization of Cyclin D1

PTEN is a tumor suppressor frequently inactivated in brain, prostate, and uterine cancers that acts as a phosphatase on phosphatidylinositol-3,4,5-trisphosphate, antagonizing the activity of the phosphatidylinositol 3′-OH kinase. PTEN manifests its tumor suppressor function in most tumor cells by in...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Radu, Aurelian, Neubauer, Valerie, Akagi, Tsuyoshi, Hanafusa, Hidesaburo, Georgescu, Maria-Magdalena
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2003
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC180959/
https://ncbi.nlm.nih.gov/pubmed/12917336
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.23.17.6139-6149.2003
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