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Age-related accumulation of Ig V(H) gene somatic mutations in peripheral B cells from aged humans
To investigate age-related alterations in human humoral immunity, we analysed Ig heavy chain variable region genes expressed by peripheral B cells from young and aged individuals. Three hundred and twenty-seven cDNA sequences, 163 µ and 164 γ transcripts with V(H)5 family genes, were analysed for so...
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| Główni autorzy: | , , , , , |
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| Format: | Artigo |
| Język: | Inglês |
| Wydane: |
Blackwell Publishing Inc
2003
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| Hasła przedmiotowe: | |
| Dostęp online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1808746/ https://ncbi.nlm.nih.gov/pubmed/12823279 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1046/j.1365-2249.2003.02185.x |
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