Age-related accumulation of Ig V(H) gene somatic mutations in peripheral B cells from aged humans

To investigate age-related alterations in human humoral immunity, we analysed Ig heavy chain variable region genes expressed by peripheral B cells from young and aged individuals. Three hundred and twenty-seven cDNA sequences, 163 µ and 164 γ transcripts with V(H)5 family genes, were analysed for so...

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Detalhes bibliográficos
Main Authors: CHONG, Y, IKEMATSU, H, YAMAJI, K, NISHIMURA, M, KASHIWAGI, S, HAYASHI, J
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Publishing Inc 2003
Assuntos:
Basic Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1808746/
https://ncbi.nlm.nih.gov/pubmed/12823279
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1046/j.1365-2249.2003.02185.x
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