V(H) and Vκ Segment Structure of Anti-Insulin IgG Autoantibodies in Patients with Insulin-Dependent Diabetes Mellitus: Evidence for Somatic Selection()

In some patients with insulin-dependent (type I) diabetes mellitus (IDDM), autoantibodies to insulin are present at diagnosis. After initiation of the treatment with not only animal but also human insulin, anti-insulin, mainly IgG, autoantibodies become a major component of the autoimmune response i...

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Veröffentlicht in:J Immunol
Hauptverfasser: Ikematsu, Hideyuki, Ichiyoshi, Yuji, Schettino, Edward W., Nakamura, Minoru, Casali, Paolo
Format: Artigo
Sprache:Inglês
Veröffentlicht: 1994
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4631048/
https://ncbi.nlm.nih.gov/pubmed/8301143
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