Clearance of red cells by monoclonal IgG3 anti-D in vivo is affected by the VF polymorphism of Fcγ RIIIa (CD16)

Human red cells (RBC) coated with IgG anti-D are cleared from the circulation to the spleen by macrophages which express IgG receptors (Fcγ R). Polymorphisms of Fcγ RIIa and Fcγ RIIIa affect IgG binding in vitro, and may alter the efficiency of clearance of immune complexes in vivo. In a RBC clearan...

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Detalhes bibliográficos
Main Authors: KUMPEL, B M, DE HAAS, M, KOENE, H R, VAN DE WINKEL, J G J, GOODRICK, M J
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Science Inc 2003
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Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1808672/
https://ncbi.nlm.nih.gov/pubmed/12653840
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1046/j.1365-2249.2003.02119.x
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