IgG antibodies to dengue enhanced for FcγRIIIA binding determine disease severity

Dengue virus (DENV) infection in the presence of reactive, non-neutralizing IgG (RNNIg) is the greatest risk factor for dengue hemorrhagic fever (DHF) or shock syndrome (DSS). Progression to DHF/DSS is attributed to antibody-dependent enhancement (ADE); however, since only a fraction of infections o...

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Publicado no:Science
Principais autores: Wang, Taia T., Sewatanon, Jaturong, Memoli, Matthew J., Wrammert, Jens, Bournazos, Stylianos, Kumar Bhaumik, Siddhartha, Pinsky, Benjamin A., Chokephaibulkit, Kulkanya, Onlamoon, Nattawat, Pattanapanyasat, Kovit, Taubenberger, Jeffery K., Ahmed, Rafi, Ravetch, Jeffrey V.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5557095/
https://ncbi.nlm.nih.gov/pubmed/28126818
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aai8128
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