IgG antibodies to dengue enhanced for FcγRIIIA binding determine disease severity

Dengue virus (DENV) infection in the presence of reactive, non-neutralizing IgG (RNNIg) is the greatest risk factor for dengue hemorrhagic fever (DHF) or shock syndrome (DSS). Progression to DHF/DSS is attributed to antibody-dependent enhancement (ADE); however, since only a fraction of infections o...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Science
Prif Awduron: Wang, Taia T., Sewatanon, Jaturong, Memoli, Matthew J., Wrammert, Jens, Bournazos, Stylianos, Kumar Bhaumik, Siddhartha, Pinsky, Benjamin A., Chokephaibulkit, Kulkanya, Onlamoon, Nattawat, Pattanapanyasat, Kovit, Taubenberger, Jeffery K., Ahmed, Rafi, Ravetch, Jeffrey V.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2017
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5557095/
https://ncbi.nlm.nih.gov/pubmed/28126818
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aai8128
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