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IgG antibodies to dengue enhanced for FcγRIIIA binding determine disease severity
Dengue virus (DENV) infection in the presence of reactive, non-neutralizing IgG (RNNIg) is the greatest risk factor for dengue hemorrhagic fever (DHF) or shock syndrome (DSS). Progression to DHF/DSS is attributed to antibody-dependent enhancement (ADE); however, since only a fraction of infections o...
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| Published in: | Science |
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| Main Authors: | , , , , , , , , , , , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
2017
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5557095/ https://ncbi.nlm.nih.gov/pubmed/28126818 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aai8128 |
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