IgG antibodies to dengue enhanced for FcγRIIIA binding determine disease severity

Dengue virus (DENV) infection in the presence of reactive, non-neutralizing IgG (RNNIg) is the greatest risk factor for dengue hemorrhagic fever (DHF) or shock syndrome (DSS). Progression to DHF/DSS is attributed to antibody-dependent enhancement (ADE); however, since only a fraction of infections o...

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Publicat a:Science
Autors principals: Wang, Taia T., Sewatanon, Jaturong, Memoli, Matthew J., Wrammert, Jens, Bournazos, Stylianos, Kumar Bhaumik, Siddhartha, Pinsky, Benjamin A., Chokephaibulkit, Kulkanya, Onlamoon, Nattawat, Pattanapanyasat, Kovit, Taubenberger, Jeffery K., Ahmed, Rafi, Ravetch, Jeffrey V.
Format: Artigo
Idioma:Inglês
Publicat: 2017
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5557095/
https://ncbi.nlm.nih.gov/pubmed/28126818
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aai8128
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