IgG antibodies to dengue enhanced for FcγRIIIA binding determine disease severity

Dengue virus (DENV) infection in the presence of reactive, non-neutralizing IgG (RNNIg) is the greatest risk factor for dengue hemorrhagic fever (DHF) or shock syndrome (DSS). Progression to DHF/DSS is attributed to antibody-dependent enhancement (ADE); however, since only a fraction of infections o...

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Bibliographic Details
Published in:Science
Main Authors: Wang, Taia T., Sewatanon, Jaturong, Memoli, Matthew J., Wrammert, Jens, Bournazos, Stylianos, Kumar Bhaumik, Siddhartha, Pinsky, Benjamin A., Chokephaibulkit, Kulkanya, Onlamoon, Nattawat, Pattanapanyasat, Kovit, Taubenberger, Jeffery K., Ahmed, Rafi, Ravetch, Jeffrey V.
Format: Artigo
Language:Inglês
Published: 2017
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5557095/
https://ncbi.nlm.nih.gov/pubmed/28126818
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aai8128
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