The N-linked oligosaccharide at FcγRIIIa Asn-45: an inhibitory element for high FcγRIIIa binding affinity to IgG glycoforms lacking core fucosylation

Human leukocyte receptor IIIa (FcγRIIIa) plays an important role in mediating therapeutic antibodies’ antibody-dependent cellular cytotoxicity (ADCC), which is closely related to the clinical efficacy of anticancer processes in humans in vivo. The removal of the core fucose from oligosaccharides att...

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Détails bibliographiques
Auteurs principaux: Shibata-Koyama, Mami, Iida, Shigeru, Okazaki, Akira, Mori, Katsuhiro, Kitajima-Miyama, Kazuko, Saitou, Seiji, Kakita, Shingo, Kanda, Yutaka, Shitara, Kenya, Kato, Koichi, Satoh, Mitsuo
Format: Artigo
Langue:Inglês
Publié: Oxford University Press 2009
Sujets:
Original Articles
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2639328/
https://ncbi.nlm.nih.gov/pubmed/18952826
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/glycob/cwn110
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