Two mechanisms of the enhanced antibody-dependent cellular cytotoxicity (ADCC) efficacy of non-fucosylated therapeutic antibodies in human blood

BACKGROUND: Antibody-dependent cellular cytotoxicity (ADCC) has recently been identified as one of the critical mechanisms underlying the clinical efficacy of therapeutic antibodies, especially anticancer antibodies. Therapeutic antibodies fully lacking the core fucose of the Fc oligosaccharides hav...

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Main Authors: Iida, Shigeru, Kuni-Kamochi, Reiko, Mori, Katsuhiro, Misaka, Hirofumi, Inoue, Miho, Okazaki, Akira, Shitara, Kenya, Satoh, Mitsuo
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2009
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2649154/
https://ncbi.nlm.nih.gov/pubmed/19226457
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2407-9-58
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