Double knockdown of α1,6-fucosyltransferase (FUT8) and GDP-mannose 4,6-dehydratase (GMD) in antibody-producing cells: a new strategy for generating fully non-fucosylated therapeutic antibodies with enhanced ADCC

BACKGROUND: Antibody-dependent cellular cytotoxicity (ADCC) is greatly enhanced by the absence of the core fucose of oligosaccharides attached to the Fc, and is closely related to the clinical efficacy of anticancer activity in humans in vivo. Unfortunately, all licensed therapeutic antibodies and a...

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Detalhes bibliográficos
Main Authors: Imai-Nishiya, Harue, Mori, Katsuhiro, Inoue, Miho, Wakitani, Masako, Iida, Shigeru, Shitara, Kenya, Satoh, Mitsuo
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2007
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2216013/
https://ncbi.nlm.nih.gov/pubmed/18047682
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1472-6750-7-84
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