FcγRIIIa SNPs and haplotypes affect human IgG binding and association with lupus nephritis in African Americans

OBJECTIVE: To investigate whether the FcγRIIIa-66R/H/L polymorphism influences net effective receptor function and to assess if the FCGR3A combined genotypes formed by FcγRIIIa-66R/H/L and FcγRIIIa-176F/V as well as copy number variation (CNV) confer risk for development of SLE and lupus nephritis....

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Main Authors: Dong, Chaoling, Ptacek, Travis S, Redden, David T, Zhang, Kui, Brown, Elizabeth E., Edberg, Jeffrey C., McGwin, Gerald, Alarcón, Graciela S., Ramsey-Goldman, Rosalind, Reveille, John D., Vilá, Luis M., Petri, Michelle, Qin, Aijian, Wu, Jianming, Kimberly, Robert P.
Format: Artigo
Language:Inglês
Published: 2014
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4069204/
https://ncbi.nlm.nih.gov/pubmed/24782186
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/art.38337
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