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SITE-DIRECTED MUTAGENESIS IN THE FINGERS SUBDOMAIN OF HIV-1 REVERSE TRANSCRIPTASE REVEALS A SPECIFIC ROLE FOR THE β3-β4 HAIRPIN LOOP IN dNTP SELECTION
HIV-1 reverse transcriptase shares the key features of high fidelity polymerases, such as a closed architecture of the active site but displays a level of fidelity that is intermediate to that of high fidelity, replicative polymerases and low fidelity translesion synthesis (TLS) polymerases. The β3-...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2006
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1808332/ https://ncbi.nlm.nih.gov/pubmed/17055529 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2006.09.057 |
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