SITE-DIRECTED MUTAGENESIS IN THE FINGERS SUBDOMAIN OF HIV-1 REVERSE TRANSCRIPTASE REVEALS A SPECIFIC ROLE FOR THE β3-β4 HAIRPIN LOOP IN dNTP SELECTION

HIV-1 reverse transcriptase shares the key features of high fidelity polymerases, such as a closed architecture of the active site but displays a level of fidelity that is intermediate to that of high fidelity, replicative polymerases and low fidelity translesion synthesis (TLS) polymerases. The β3-...

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Hauptverfasser: Garforth, Scott J., Kim, Tae Woo, Parniak, Michael A., Kool, Eric T., Prasad, Vinayaka R.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2006
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1808332/
https://ncbi.nlm.nih.gov/pubmed/17055529
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2006.09.057
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