dNTP-dependent Conformational Transitions in the Fingers Subdomain of Klentaq1 DNA Polymerase: INSIGHTS INTO THE ROLE OF THE “NUCLEOTIDE-BINDING” STATE

DNA polymerases are responsible for the accurate replication of DNA. Kinetic, single-molecule, and x-ray studies show that multiple conformational states are important for DNA polymerase fidelity. Using high precision FRET measurements, we show that Klentaq1 (the Klenow fragment of Thermus aquaticus...

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Detalhes bibliográficos
Main Authors: Rothwell, Paul J., Allen, William J., Sisamakis, Evangelos, Kalinin, Stanislav, Felekyan, Suren, Widengren, Jerker, Waksman, Gabriel, Seidel, Claus A. M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2013
Assuntos:
Molecular Biophysics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3650393/
https://ncbi.nlm.nih.gov/pubmed/23525110
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.432690
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