Reduced Susceptibility of Haemophilus influenzae to the Peptide Deformylase Inhibitor LBM415 Can Result from Target Protein Overexpression Due to Amplified Chromosomal def Gene Copy Number

Previous genetic analysis of Haemophilus influenzae revealed two mechanisms associated with decreased susceptibility to the novel peptide deformylase inhibitor LBM415: AcrAB-TolC-mediated efflux and Fmt bypass, resulting from mutations in the pump repressor gene acrR and in the fmt gene, respectivel...

Cijeli opis

Spremljeno u:
Bibliografski detalji
Glavni autori: Dean, Charles R., Narayan, Shubha, Richards, Joel, Daigle, Denis M., Esterow, Stacy, Leeds, Jennifer A., Kamp, Heather, Puyang, Xiaoling, Wiedmann, Brigitte, Mueller, Dieter, Voshol, Hans, van Oostrum, Jan, Wall, Daniel, Koehn, James, Dzink-Fox, JoAnn, Ryder, Neil S.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2007
Teme:
Mechanisms of Resistance
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1803149/
https://ncbi.nlm.nih.gov/pubmed/17220413
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01103-06
Oznake: Dodaj oznaku
Bez oznaka, Budi prvi tko označuje ovaj zapis!

Similar Items