Reduced Susceptibility of Haemophilus influenzae to the Peptide Deformylase Inhibitor LBM415 Can Result from Target Protein Overexpression Due to Amplified Chromosomal def Gene Copy Number

Previous genetic analysis of Haemophilus influenzae revealed two mechanisms associated with decreased susceptibility to the novel peptide deformylase inhibitor LBM415: AcrAB-TolC-mediated efflux and Fmt bypass, resulting from mutations in the pump repressor gene acrR and in the fmt gene, respectivel...

Celý popis

Uloženo v:
Podrobná bibliografie
Hlavní autoři: Dean, Charles R., Narayan, Shubha, Richards, Joel, Daigle, Denis M., Esterow, Stacy, Leeds, Jennifer A., Kamp, Heather, Puyang, Xiaoling, Wiedmann, Brigitte, Mueller, Dieter, Voshol, Hans, van Oostrum, Jan, Wall, Daniel, Koehn, James, Dzink-Fox, JoAnn, Ryder, Neil S.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2007
Témata:
Mechanisms of Resistance
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1803149/
https://ncbi.nlm.nih.gov/pubmed/17220413
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01103-06
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky