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A cooperative oxygen-binding hemoglobin from Mycobacterium tuberculosis

Two putative hemoglobin genes, glbN and glbO, were recently discovered in the complete genome sequence of Mycobacterium tuberculosis H37Rv. Here, we show that the glbN gene encodes a dimeric hemoglobin (HbN) that binds oxygen cooperatively with very high affinity (P(50) = 0.013 mmHg at 20°C) because...

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Detalhes bibliográficos
Main Authors: Couture, Manon, Yeh, Syun-Ru, Wittenberg, Beatrice A., Wittenberg, Jonathan B., Ouellet, Yannick, Rousseau, Denis L., Guertin, Michel
Formato: Artigo
Idioma:Inglês
Publicado em: The National Academy of Sciences 1999
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC18015/
https://ncbi.nlm.nih.gov/pubmed/10500158
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