A cooperative oxygen-binding hemoglobin from Mycobacterium tuberculosis

Two putative hemoglobin genes, glbN and glbO, were recently discovered in the complete genome sequence of Mycobacterium tuberculosis H37Rv. Here, we show that the glbN gene encodes a dimeric hemoglobin (HbN) that binds oxygen cooperatively with very high affinity (P(50) = 0.013 mmHg at 20°C) because...

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Pubblicato in:	Proc Natl Acad Sci U S A
Autori principali:	Couture, Manon, Yeh, Syun-Ru, Wittenberg, Beatrice A., Wittenberg, Jonathan B., Ouellet, Yannick, Rousseau, Denis L., Guertin, Michel
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	National Academy of Sciences 1999
Soggetti:	Biological Sciences
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC18015/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10500158/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.96.20.11223
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