Pharmacokinetics of imipenem-cilastatin in neonates.

Imipenem and its renal dehydropeptidase I inhibitor, cilastatin, were coadministered intravenously in a 1:1 ratio to 30 newborns. Five infants each received single doses of 10, 15, or 20 mg/kg of both drugs. Concentrations in plasma were proportional to the administered dose, and cilastatin achieved...

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Detalhes bibliográficos

Publicado no:	Antimicrob Agents Chemother
Principais autores:	Freij, B J, McCracken, G H, Olsen, K D, Threlkeld, N
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 1985
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC180068/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3859242/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.27.4.431
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