Multiple-dose pharmacokinetics of imipenem-cilastatin.

We characterized the pharmacokinetic profile of imipenem-cilastatin administered intravenously to six normal volunteers in a dose of 1,000 mg of each drug every 6 h for 40 doses. The plasma concentrations of imipenem and cilastatin 1 h after the end of a 30-min infusion were 18.7 (+/- 2.1) and 19.1...

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Bibliographic Details
Main Authors: Drusano, G L, Standiford, H C, Bustamante, C, Forrest, A, Rivera, G, Leslie, J, Tatem, B, Delaportas, D, MacGregor, R R, Schimpff, S C
Format: Artigo
Language:Inglês
Published: 1984
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC180001/
https://ncbi.nlm.nih.gov/pubmed/6595963
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