Multiple-dose pharmacokinetics of imipenem-cilastatin.

We characterized the pharmacokinetic profile of imipenem-cilastatin administered intravenously to six normal volunteers in a dose of 1,000 mg of each drug every 6 h for 40 doses. The plasma concentrations of imipenem and cilastatin 1 h after the end of a 30-min infusion were 18.7 (+/- 2.1) and 19.1...

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Detalhes bibliográficos

Publicado no:	Antimicrob Agents Chemother
Principais autores:	Drusano, G L, Standiford, H C, Bustamante, C, Forrest, A, Rivera, G, Leslie, J, Tatem, B, Delaportas, D, MacGregor, R R, Schimpff, S C
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 1984
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC180001/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6595963/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.26.5.715
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