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Loss of Hsp90 Association Up-Regulates Src-Dependent ErbB2 Activity
The receptor tyrosine kinase ErbB2 plays a crucial role in tumorigenesis. We showed previously that the molecular chaperone Hsp90 protects ErbB2 from proteasome-mediated degradation by binding to a short loop structure in the N-lobe of the kinase domain. Here we show that loss of Hsp90 binding corre...
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| 主要な著者: | , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
American Society for Microbiology
2007
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1800645/ https://ncbi.nlm.nih.gov/pubmed/17030621 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00899-06 |
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