Decreased activity of UMP pyrophosphorylase associated with resistance to 5-fluorocytosine in Candida albicans.

UMP pyrophosphorylase activity was assayed in crude lysates prepared from Candida albicans. Specific activity of UMP pyrophosphorylase was high in clinical isolates which were susceptible to 5-fluorocytosine. Resistant clinical isolates displayed low activity, and partially resistant (heterozygous)...

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Vydáno v:	Antimicrob Agents Chemother
Hlavní autoři:	Whelan, W L, Kerridge, D
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	American Society for Microbiology (ASM) 1984
Témata:	Research Article
On-line přístup:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC179965/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6393861/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.26.4.570
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