Decreased activity of UMP pyrophosphorylase associated with resistance to 5-fluorocytosine in Candida albicans.

UMP pyrophosphorylase activity was assayed in crude lysates prepared from Candida albicans. Specific activity of UMP pyrophosphorylase was high in clinical isolates which were susceptible to 5-fluorocytosine. Resistant clinical isolates displayed low activity, and partially resistant (heterozygous)...

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Publicado en:	Antimicrob Agents Chemother
Autores principales:	Whelan, W L, Kerridge, D
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	American Society for Microbiology (ASM) 1984
Materias:	Research Article
Acceso en línea:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC179965/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6393861/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.26.4.570
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