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Complex effects of rexinoids on ligand dependent activation or inhibition of the xenobiotic receptor, CAR
BACKGROUND: CAR/RXR heterodimers bind a variety of hormone response elements and activate transcription in the absence of added ligands. This constitutive activity of murine CAR can be inhibited by the inverse agonist ligand androstanol or increased by the agonist TCPOBOP. RXR agonists activate some...
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| Hauptverfasser: | , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
BioMed Central
2003
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC179875/ https://ncbi.nlm.nih.gov/pubmed/12904257 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1478-1336-1-2 |
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