Complex effects of rexinoids on ligand dependent activation or inhibition of the xenobiotic receptor, CAR

BACKGROUND: CAR/RXR heterodimers bind a variety of hormone response elements and activate transcription in the absence of added ligands. This constitutive activity of murine CAR can be inhibited by the inverse agonist ligand androstanol or increased by the agonist TCPOBOP. RXR agonists activate some...

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Bibliographic Details
Main Authors: Tzameli, Iphigenia, Chua, Steven S, Cheskis, Boris, Moore, David D
Format: Artigo
Language:Inglês
Published: BioMed Central 2003
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Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC179875/
https://ncbi.nlm.nih.gov/pubmed/12904257
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1478-1336-1-2
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