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Sublethal Concentrations of the Aminoglycoside Amikacin Interfere with Cell Division without Affecting Chromosome Dynamics

Aminoglycosides bind to the 16S rRNA at the tRNA acceptor site (A site) and disturb protein synthesis by inducing codon misreading. We investigated Escherichia coli cell elongation and division, as well as the dynamics of chromosome replication and segregation, in the presence of sublethal concentra...

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Autores principales: Possoz, Christophe, Newmark, Jason, Sorto, Nohemy, Sherratt, David J., Tolmasky, Marcelo E.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2007
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1797645/
https://ncbi.nlm.nih.gov/pubmed/17043119
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00892-06
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