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External Guide Sequences Targeting the aac(6′)-Ib mRNA Induce Inhibition of Amikacin Resistance

The dissemination of AAC(6′)-I-type acetyltransferases have rendered amikacin and other aminoglycosides all but useless in some parts of the world. Antisense technologies could be an alternative to extend the life of these antibiotics. External guide sequences are short antisense oligoribonucleotide...

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Bibliografske podrobnosti
Main Authors: Bistué, Alfonso J. C. Soler, Ha, Hongphuc, Sarno, Renee, Don, Michelle, Zorreguieta, Angeles, Tolmasky, Marcelo E.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2007
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC1891410/
https://ncbi.nlm.nih.gov/pubmed/17387154
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01500-06
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