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External Guide Sequences Targeting the aac(6′)-Ib mRNA Induce Inhibition of Amikacin Resistance

The dissemination of AAC(6′)-I-type acetyltransferases have rendered amikacin and other aminoglycosides all but useless in some parts of the world. Antisense technologies could be an alternative to extend the life of these antibiotics. External guide sequences are short antisense oligoribonucleotide...

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Detalhes bibliográficos
Main Authors: Bistué, Alfonso J. C. Soler, Ha, Hongphuc, Sarno, Renee, Don, Michelle, Zorreguieta, Angeles, Tolmasky, Marcelo E.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2007
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1891410/
https://ncbi.nlm.nih.gov/pubmed/17387154
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01500-06
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