External Guide Sequences Targeting the aac(6′)-Ib mRNA Induce Inhibition of Amikacin Resistance

The dissemination of AAC(6′)-I-type acetyltransferases have rendered amikacin and other aminoglycosides all but useless in some parts of the world. Antisense technologies could be an alternative to extend the life of these antibiotics. External guide sequences are short antisense oligoribonucleotide...

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Bibliografische gegevens
Hoofdauteurs: Bistué, Alfonso J. C. Soler, Ha, Hongphuc, Sarno, Renee, Don, Michelle, Zorreguieta, Angeles, Tolmasky, Marcelo E.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Microbiology 2007
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Mechanisms of Action: Physiological Effects
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1891410/
https://ncbi.nlm.nih.gov/pubmed/17387154
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01500-06
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