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Sublethal Concentrations of the Aminoglycoside Amikacin Interfere with Cell Division without Affecting Chromosome Dynamics

Aminoglycosides bind to the 16S rRNA at the tRNA acceptor site (A site) and disturb protein synthesis by inducing codon misreading. We investigated Escherichia coli cell elongation and division, as well as the dynamics of chromosome replication and segregation, in the presence of sublethal concentra...

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Detalhes bibliográficos
Main Authors: Possoz, Christophe, Newmark, Jason, Sorto, Nohemy, Sherratt, David J., Tolmasky, Marcelo E.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2007
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1797645/
https://ncbi.nlm.nih.gov/pubmed/17043119
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00892-06
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