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Identification of the FHL2 Transcriptional Coactivator as a New Functional Target of the E7 Oncoprotein of Human Papillomavirus Type 16

We identified the transcriptional coactivator FHL2 as a novel target of the human papillomavirus type 16 (HPV-16) E7 oncoprotein, which plays a major role in cell transformation. The interaction with FHL2 is abolished by mutations in conserved regions 1 and 2 and in the C-terminal zinc finger domain...

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Autors principals: Campo-Fernández, Beatriz, Morandell, Dieter, Santer, Frédéric R., Zwerschke, Werner, Jansen-Dürr, Pidder
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2007
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1797482/
https://ncbi.nlm.nih.gov/pubmed/17093190
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01699-06
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