Modulation of type M(2) pyruvate kinase activity by the human papillomavirus type 16 E7 oncoprotein

We report here that the E7 oncoprotein encoded by the oncogenic human papillomavirus (HPV) type 16 binds to the glycolytic enzyme type M(2) pyruvate kinase (M2-PK). M2-PK occurs in a tetrameric form with a high affinity to its substrate phosphoenolpyruvate and a dimeric form with a low affinity to p...

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Autores principales: Zwerschke, Werner, Mazurek, Sybille, Massimi, Paola, Banks, Lawrence, Eigenbrodt, Erich, Jansen-Dürr, Pidder
Formato: Artigo
Lenguaje:Inglês
Publicado: The National Academy of Sciences 1999
Materias:
Biological Sciences
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC15456/
https://ncbi.nlm.nih.gov/pubmed/9990017
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