Human Papillomavirus Type 16 E7 Oncoprotein Binds and Inactivates Growth-Inhibitory Insulin-Like Growth Factor Binding Protein 3

The E7 protein encoded by human papillomavirus type 16 is one of the few viral genes that can immortalize primary human cells and thereby override cellular senescence. While it is generally assumed that this property of E7 depends on its interaction with regulators of the cell cycle, we show here th...

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Bibliographic Details
Main Authors: Mannhardt, Boris, Weinzimer, Stuart A., Wagner, Mechthild, Fiedler, Marc, Cohen, Pinchas, Jansen-Dürr, Pidder, Zwerschke, Werner
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2000
Subjects:
Cell Growth and Development
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC86123/
https://ncbi.nlm.nih.gov/pubmed/10938125
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