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Modeling evolutionary landscapes: Mutational stability, topology, and superfunnels in sequence space
Random mutations under neutral or near-neutral conditions are studied by considering plausible evolutionary trajectories on “neutral nets”—i.e., collections of sequences (genotypes) interconnected via single-point mutations encoding for the same ground-state structure (phenotype). We use simple exac...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The National Academy of Sciences
1999
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC17944/ https://ncbi.nlm.nih.gov/pubmed/10485887 |
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