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Recombinatoric exploration of novel folded structures: A heteropolymer-based model of protein evolutionary landscapes

The role of recombination in evolution is compared with that of point mutations (substitutions) in the context of a simple, polymer physics-based model mapping between sequence (genotype) and conformational (phenotype) spaces. Crossovers and point mutations of lattice chains with a hydrophobic polar...

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Detalhes bibliográficos
Main Authors: Cui, Yan, Wong, Wing Hung, Bornberg-Bauer, Erich, Chan, Hue Sun
Formato: Artigo
Idioma:Inglês
Publicado em: The National Academy of Sciences 2002
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC117387/
https://ncbi.nlm.nih.gov/pubmed/11805332
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.022240299
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