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Evolutionary Dynamics on Protein Bi-stability Landscapes can Potentially Resolve Adaptive Conflicts

Experimental studies have shown that some proteins exist in two alternative native-state conformations. It has been proposed that such bi-stable proteins can potentially function as evolutionary bridges at the interface between two neutral networks of protein sequences that fold uniquely into the tw...

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Détails bibliographiques
Auteurs principaux: Sikosek, Tobias, Bornberg-Bauer, Erich, Chan, Hue Sun
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2012
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3441461/
https://ncbi.nlm.nih.gov/pubmed/23028272
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1002659
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