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Protein topology and stability define the space of allowed sequences
We describe a new approach to explore and quantify the sequence space associated with a given protein structure. A set of sequences are optimized for a given target structure, using all-atom models and a physical energy function. Specificity of the sequence for its target is ensured by using the ran...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The National Academy of Sciences
2002
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC122181/ https://ncbi.nlm.nih.gov/pubmed/11805293 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.032405199 |
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