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β-Sheet core of human prion protein amyloid fibrils as determined by hydrogen/deuterium exchange

Propagation of transmissible spongiform encephalopathies is associated with the conversion of normal prion protein, PrP(C), into a misfolded, oligomeric form, PrP(Sc). Although the high-resolution structure of the PrP(C) is well characterized, the structural properties of PrP(Sc) remain elusive. Her...

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Bibliographic Details
Main Authors: Lu, Xiaojun, Wintrode, Patrick L., Surewicz, Witold K.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2007
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1785245/
https://ncbi.nlm.nih.gov/pubmed/17242357
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0608447104
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