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β-Sheet core of human prion protein amyloid fibrils as determined by hydrogen/deuterium exchange
Propagation of transmissible spongiform encephalopathies is associated with the conversion of normal prion protein, PrP(C), into a misfolded, oligomeric form, PrP(Sc). Although the high-resolution structure of the PrP(C) is well characterized, the structural properties of PrP(Sc) remain elusive. Her...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1785245/ https://ncbi.nlm.nih.gov/pubmed/17242357 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0608447104 |
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