Loading...

Aβ amyloid fibrils possess a core structure highly resistant to hydrogen exchange

We describe here experiments designed to characterize the secondary structure of amyloid fibrils of the Alzheimer's amyloid plaque peptide Aβ, using hydrogen-deuterium exchange measurements evaluated by mass spectrometry. The results show that ≈50% of the amide protons of the polypeptide backbo...

Full description

Saved in:
Bibliographic Details
Main Authors: Kheterpal, Indu, Zhou, Shaolian, Cook, Kelsey D., Wetzel, Ronald
Format: Artigo
Language:Inglês
Published: The National Academy of Sciences 2000
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC17621/
https://ncbi.nlm.nih.gov/pubmed/11087832
Tags: Add Tag
No Tags, Be the first to tag this record!