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Structural properties of Aβ protofibrils stabilized by a small molecule
Metastable oligomeric and protofibrillar forms of amyloidogenic proteins have been implicated as on-pathway assembly intermediates in amyloid formation and as the major toxic species in a number of amyloid diseases including Alzheimer's disease. We describe here a chemical biology approach to s...
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| Autori principali: | , , , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
National Academy of Sciences
2005
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1091746/ https://ncbi.nlm.nih.gov/pubmed/15883377 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0408582102 |
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