Structural properties of Aβ protofibrils stabilized by a small molecule

Metastable oligomeric and protofibrillar forms of amyloidogenic proteins have been implicated as on-pathway assembly intermediates in amyloid formation and as the major toxic species in a number of amyloid diseases including Alzheimer's disease. We describe here a chemical biology approach to s...

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Autors principals: Williams, Angela D., Sega, Matt, Chen, Maolian, Kheterpal, Indu, Geva, Merav, Berthelier, Valerie, Kaleta, David T., Cook, Kelsey D., Wetzel, Ronald
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2005
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1091746/
https://ncbi.nlm.nih.gov/pubmed/15883377
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0408582102
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