Aβ amyloid fibrils possess a core structure highly resistant to hydrogen exchange

We describe here experiments designed to characterize the secondary structure of amyloid fibrils of the Alzheimer's amyloid plaque peptide Aβ, using hydrogen-deuterium exchange measurements evaluated by mass spectrometry. The results show that ≈50% of the amide protons of the polypeptide backbo...

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Bibliografske podrobnosti
Main Authors: Kheterpal, Indu, Zhou, Shaolian, Cook, Kelsey D., Wetzel, Ronald
Format: Artigo
Jezik:Inglês
Izdano: The National Academy of Sciences 2000
Teme:
Biological Sciences
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC17621/
https://ncbi.nlm.nih.gov/pubmed/11087832
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