A soluble form of the Mer receptor tyrosine kinase inhibits macrophage clearance of apoptotic cells and platelet aggregation

Membrane-bound receptors generate soluble ligand-binding domains either by proteolytic cleavage of the extracellular domain or alternative mRNA splicing yielding a secreted protein. Mertk (Mer) is in a receptor tyrosine kinase family with Axl and Tyro-3, and all 3 receptors share the Gas6 ligand. Me...

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Detalhes bibliográficos
Main Authors: Sather, Susan, Kenyon, Karla D., Lefkowitz, Jerry B., Liang, Xiayuan, Varnum, Brian C., Henson, Peter M., Graham, Douglas K.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2007
Assuntos:
Hemostasis, Thrombosis, and Vascular Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1785151/
https://ncbi.nlm.nih.gov/pubmed/17047157
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2006-05-021634
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