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Regulation of Cardiac L-Type Ca(2+) Current in Na(+)-Ca(2+) Exchanger Knockout Mice: Functional Coupling of the Ca(2+) Channel and the Na(+)-Ca(2+) Exchanger
L-type Ca(2+) current (I(Ca)) is reduced in myocytes from cardiac-specific Na(+)-Ca(2+) exchanger (NCX) knockout (KO) mice. This is an important adaptation to prevent Ca(2+) overload in the absence of NCX. However, Ca(2+) channel expression is unchanged, suggesting that regulatory processes reduce I...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Biophysical Society
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1783897/ https://ncbi.nlm.nih.gov/pubmed/17114214 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1529/biophysj.106.091538 |
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