Contribution of small conductance K(+) channels to sinoatrial node pacemaker activity: insights from atrial‐specific Na(+)/Ca(2+) exchange knockout mice

KEY POINTS: Repolarizing currents through K(+) channels are essential for proper sinoatrial node (SAN) pacemaking, but the influence of intracellular Ca(2+) on repolarization in the SAN is uncertain. We identified all three isoforms of Ca(2+)‐activated small conductance K(+) (SK) channels in the mur...

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Publicat a:J Physiol
Autors principals: Torrente, Angelo G., Zhang, Rui, Wang, Heidi, Zaini, Audrey, Kim, Brian, Yue, Xin, Philipson, Kenneth D., Goldhaber, Joshua I.
Format: Artigo
Idioma:Inglês
Publicat: John Wiley and Sons Inc. 2017
Matèries:
Cardiac Excitation Contraction Coupling and Calcium Signalling
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5471364/
https://ncbi.nlm.nih.gov/pubmed/28346695
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/JP274249
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