Burst pacemaker activity of the sinoatrial node in sodium–calcium exchanger knockout mice

In sinoatrial node (SAN) cells, electrogenic sodium–calcium exchange (NCX) is the dominant calcium (Ca) efflux mechanism. However, the role of NCX in the generation of SAN automaticity is controversial. To investigate the contribution of NCX to pacemaking in the SAN, we performed optical voltage map...

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Bibliografiske detaljer
Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Torrente, Angelo G., Zhang, Rui, Zaini, Audrey, Giani, Jorge F., Kang, Jeanney, Lamp, Scott T., Philipson, Kenneth D., Goldhaber, Joshua I.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2015
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4534240/
https://ncbi.nlm.nih.gov/pubmed/26195795
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1505670112
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