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Burst pacemaker activity of the sinoatrial node in sodium–calcium exchanger knockout mice

In sinoatrial node (SAN) cells, electrogenic sodium–calcium exchange (NCX) is the dominant calcium (Ca) efflux mechanism. However, the role of NCX in the generation of SAN automaticity is controversial. To investigate the contribution of NCX to pacemaking in the SAN, we performed optical voltage map...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Torrente, Angelo G., Zhang, Rui, Zaini, Audrey, Giani, Jorge F., Kang, Jeanney, Lamp, Scott T., Philipson, Kenneth D., Goldhaber, Joshua I.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4534240/
https://ncbi.nlm.nih.gov/pubmed/26195795
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1505670112
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