Activation of reverse Na(+)–Ca(2+) exchange by the Na(+) current augments the cardiac Ca(2+) transient: evidence from NCX knockout mice

The hypothesis that Na(+) influx during the action potential (AP) activates reverse Na(+)–Ca(2+) exchange (NCX) and subsequent entry of trigger Ca(2+) is controversial. We tested this hypothesis by monitoring intracellular Ca(2+) before and after selective inactivation of I(Na) prior to a simulated...

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Bibliografiske detaljer
Main Authors: Larbig, Robert, Torres, Natalia, Bridge, John H B, Goldhaber, Joshua I, Philipson, Kenneth D
Format: Artigo
Sprog:Inglês
Udgivet: Blackwell Science Inc 2010
Fag:
Cardiovascular
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2976021/
https://ncbi.nlm.nih.gov/pubmed/20643777
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2010.187708
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