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Activation of reverse Na(+)–Ca(2+) exchange by the Na(+) current augments the cardiac Ca(2+) transient: evidence from NCX knockout mice
The hypothesis that Na(+) influx during the action potential (AP) activates reverse Na(+)–Ca(2+) exchange (NCX) and subsequent entry of trigger Ca(2+) is controversial. We tested this hypothesis by monitoring intracellular Ca(2+) before and after selective inactivation of I(Na) prior to a simulated...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Blackwell Science Inc
2010
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2976021/ https://ncbi.nlm.nih.gov/pubmed/20643777 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2010.187708 |
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